Housed in a historic railroad depot on the banks of the Mississippi River, the Louisiana Art & Science Museum offers educational and entertainment opportunities for visitors of all ages. Featured are changing fine art exhibitions, interactive art and science galleries for children, the Ancient Egypt Gallery, and simulated space travel in the Challenger Learning Center. In addition, the center offers lectures, workshops, and classes. LASM is also home to the Irene W. Pennington Planetarium and ExxonMobil Space Theater, which offers planetarium shows and large-format films.

LASM is accredited by the American Association of Museums and is a member of the Association of Science and Technology Centers.

These programs have been made possible in part through the generous support of the Arts Council of Greater Baton Rouge and the Community Fund for the Arts Campaign and supported by a grant from the National Endowment for the Arts, the Louisiana State Arts Council, the Louisiana Division of the Arts, Office of Cultural Development, Department of Culture, Recreation and Tourism, and the U.S. Department of Education.